Modelling reaction kinetics inside cells

Modelling reaction kinetics inside cells.

In the past decade, advances in molecular biology such as the development of non-invasive single molecule imaging techniques have given us a window into the intricate biochemical activities that occur inside cells. In this chapter we review four distinct theoretical and simulation frameworks: (i) non-spatial and deterministic, (ii) spatial and deterministic, (iii) non-spatial and stochastic and...

Hybridization kinetics is different inside cells.

It is generally expected that the kinetics of reactions inside living cells differs from the situation in bulk solutions. Macromolecular crowding and specific binding interactions could change the diffusion properties and the availability of free molecules. Their impact on reaction kinetics in the relevant context of living cells is still elusive, mainly because the difficulty of capturing fast...

Enhanced reaction kinetics in biological cells

The cell cytoskeleton is a striking example of " active " medium driven out-of-equilibrium by ATP hydrolysis 1. Such activity has been shown recently to have a spectacular impact on the mechanical and rheological properties of the cellular medium : a generic tracer particle freely diffuses as in a standard equilibrium medium, but also intermittently binds with random interaction times to motor ...

Molecular Reaction Kinetics inside Channel Pores: Delayed Fluorescence of Naphthalene in Methanol

A one-dimensional, diffusion-controlled, reaction is followed in time by phosphorescence (monitoring reactant) and delayed fluorescence (moniloring product). The triplet (excited) naphthalene molecules move in a methanol solution, confined inside the cylindrical channels of a channel-pore polycarbonate membrane. The reaction product is a transient photodimer or excimer, giving delayed fluoresce...

Diffusion-Controlled Reaction Kinetics